Orphanet: Hereditary combined deficiency of vitamin K dependent clotting factors

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Hereditary combined deficiency of vitamin K-dependent clotting factors

Disease definition

Combined vitamin K-dependent clotting factors deficiency (VKCFD) is a congenital bleeding disorder resulting from variably decreased levels of coagulation factors II, VII, IX and X, as well as natural anticoagulants protein C, protein S and protein Z.


  • Synonym(s):
    • Hereditary combined deficiency of factors II, VII, IX and X
  • Prevalence: <1 / 1 000 000
  • Inheritance: Autosomal recessive 
  • Age of onset: Infancy, Neonatal
  • ICD-10: D68.2
  • OMIM: 277450  607473
  • UMLS: C1848534
  • MeSH: -
  • GARD: -
  • MedDRA: -

Detailed information

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