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Familial hypofibrinogenemia

Synonym(s) -
Prevalence Unknown
Inheritance Autosomal dominant
Age of onset All ages
  • D68.2
MeSH -
MedDRA -


Disease definition

Familial hypofibrinogenemia is a coagulation disorder characterized by mild bleeding symptoms following trauma or surgery due to a reduced plasma fibrinogen concentration.


Prevalence is unknown but hypofibrinogenemia is more frequent than afibrinogenemia which has a prevalence of 1/1,000,000.


The deficiency is due to various mutations in the FGA, FGB, or FGG genes.

Genetic counseling

Transmission is mainly autosomal dominant.

Expert reviewer(s)

  • Pr Jenny GOUDEMAND

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