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Undifferentiated pleomorphic sarcoma

Disease definition

Undifferentiated pleomorphic sarcoma (UPS) is an aggressive sarcoma of soft tissues or bone that can arise from any part of the body, clinically presenting as swelling, mass, pain, pathological fracture and occasional systemic features and is characterized by high local recurrence and significant metastasis.

ORPHA:2023

  • Synonym(s):
    • UPS
  • Prevalence: 1-9 / 100 000
  • Inheritance: Not applicable 
  • Age of onset: Childhood, Adolescent, Adult, Elderly
  • ICD-10: C49.9
  • OMIM: -
  • UMLS: C0334463
  • MeSH: D051677
  • GARD: 6963
  • MedDRA: 10025552

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