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Mikulicz disease

Orpha number ORPHA79078
Synonym(s) Chronic dacryoadenitis and sialoadenitis
IgG4-related dacryoadenitis and sialoadenitis
Prevalence Unknown
Inheritance -
Age of onset All ages
ICD-10
  • K11.8
ICD-O -
OMIM -
UMLS
  • C0026103
MeSH
  • D008882
MedDRA
  • 10051457
  • 10052317

Summary

Mikulicz's disease is an IgG4-related sclerosing disease (see this term) characterized by persistent, usually painless, bilateral enlargement of the lacrimal, parotid, and submandibular glands associated with elevated levels of serum immunoglobulin (Ig) G4 and with lymphocyte and IgG4-positive plasmacyte infiltration. It predominantly causes mouth and eye dryness but can also affect other organs such as the lungs, liver, and kidneys, and be accompanied by complications such as autoimmune pancreatitis (AIP), retroperitoneal fibrosis, and tubulointerstitial nephritis (see these terms).


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Detailed information

Summary information
Review article
  • EN (2014)
Diagnostic criteria
  • EN (2014,pdf)
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