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Mikulicz disease

Synonym(s) Chronic dacryoadenitis and sialoadenitis
IgG4-related dacryoadenitis and sialoadenitis
Prevalence Unknown
Inheritance -
Age of onset All ages
  • K11.8
  • C0026103
  • D008882
  • 10051457
  • 10052317


Mikulicz's disease is an IgG4-related sclerosing disease (see this term) characterized by persistent, usually painless, bilateral enlargement of the lacrimal, parotid, and submandibular glands associated with elevated levels of serum immunoglobulin (Ig) G4 and with lymphocyte and IgG4-positive plasmacyte infiltration. It predominantly causes mouth and eye dryness but can also affect other organs such as the lungs, liver, and kidneys, and be accompanied by complications such as autoimmune pancreatitis (AIP), retroperitoneal fibrosis, and tubulointerstitial nephritis (see these terms).

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Detailed information

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Diagnostic criteria
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