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Wells syndrome

Orpha number ORPHA901
Synonym(s) Eosinophilic cellulitis
Prevalence <1 / 1 000 000
Inheritance Not applicable
Age of onset Adult
ICD-10
  • L98.3
ICD-O -
OMIM -
UMLS
  • C0343101
MeSH
  • C536693
MedDRA -
SNOMED CT -

Summary

Wells syndrome is characterised by the presence of recurrent cellulitis-like eruptions with eosinophilia. Approximately 80 cases have been described in the literature. The lesions are usually filled with fluid, tender and progress to form hardened plaques of edema and erythema. They usually resolve without scarring. Histological studies reveal flame figures and heavy infiltration of eosinophils and histiocytes. The syndrome is usually sporadic but familial cases have been reported.


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