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Wells syndrome

Synonym(s) Eosinophilic cellulitis
Prevalence <1 / 1 000 000
Inheritance Not applicable
Age of onset Adult
  • L98.3
  • C0343101
  • C536693
MedDRA -


Disease definition

Wells syndrome is characterised by the presence of recurrent cellulitis-like eruptions with eosinophilia.


Approximately 80 cases have been described in the literature.

Clinical description

The lesions are usually filled with fluid, tender and progress to form hardened plaques of edema and erythema. They usually resolve without scarring.

Diagnostic methods

Histological studies reveal flame figures and heavy infiltration of eosinophils and histiocytes.

Genetic counseling

The syndrome is usually sporadic but familial cases have been reported.

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