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Research projects

OBERÖSTERREICH
LINZ
AMLSG BiO: Registry Study on Patient Characteristics, Biological Disease Profile and Clinical Outcome in Acute Myeloid Leukemia and Related Neoplasms, and Higher Risk Myelodysplastic Syndrome - The Biology and Outcome (BiO)-Project - AT
Krankenhaus der Barmherzigen Schwestern Linz
Interne I - Internistische Onkologie, Hämatologie u. Gastroenterologie

STEIERMARK
GRAZ
The role of RKIP in myeloid leukemogenesis
Medizinische Universität Graz
Klinische Abteilung für Hämatologie

WIEN
WIEN
Functional characterization of a receptor protein associated with poor therapy response and relapse of acute myeloid leukemia
Allgemeines Krankenhaus der Stadt Wien
Klinische Abteilung für Onkologie

WIEN
WIEN
Functional interactions between EVI1 and atRA in LSCs (in acute myeloid leukemia)
Allgemeines Krankenhaus der Stadt Wien
Klinische Abteilung für Onkologie

VLAAMS BRABANT
LEUVEN
The role of RAS- and RHO-GTPases, their regulators and mediators in the pathogenesis of myeloid malignancies.
University Hospitals Leuven - Gasthuisberg
Laboratory for Genetics of Malignant Disorders

Ontario
TORONTO
CD123-Targeted Auger Electron Radioimmunotherapy of Acute Myelogenous Leukemia (AML)
University of Toronto
Leslie Dan Faculty of Pharmacy, University of Toronto

Baden-Württemberg
HEIDELBERG
INFORM-Registry: INdividualized Therapy FOr Relapsed Malignancies in Childhood
Deutsches Krebsforschungszentrum
Klinische Kooperationseinheit Pädiatrische Onkologie

Baden-Württemberg
HEIDELBERG
AMLSG BIO: Registry study on biological disease profile and clinical outcome in Acute Myeloid Leukemia and related neoplasms, and Acute Leukemias of Ambiguous Lineage - The AMLSG Biology and Outcome (BiO)-Project
Nationales Centrum für Tumorerkrankungen (NCT)
Nationales Centrum für Tumorerkrankungen (CCC) Heidelberg

Baden-Württemberg
MANNHEIM
EUROPEAN LEUKEMIA NET: Strengthen and develop scientific and technological excellence in research and therapy of leukemia (coordination)
Universitätsklinikum Mannheim
III. Medizinische Klinik - Prof. Hehlmann

Baden-Württemberg
ULM
Pathogenetic relevance of the human leukemia specific fusion gene TEL -CDX2 and the homeobox gene CDX2 in t(12;13)(p13;q12)-positive acute myeloic leukemia
Universitätsklinikum Ulm
Institut für Experimentelle Tumorforschung

Baden-Württemberg
ULM
Impact of the fusion gene CALM - AF10 expression in the pathogenesis of t(10;11)(p13q14) positive leukemia (German Cancer Aid)
Universitätsklinikum Ulm
Institut für Experimentelle Tumorforschung

Baden-Württemberg
ULM
Characterising normal versus leukemic stem cells in patients with acute myeloic leukemia (German Cancer Aid)
Universitätsklinikum Ulm
Institut für Experimentelle Tumorforschung

Baden-Württemberg
ULM
Evaluation of Incidence and Prognostic Importance of Gene Mutations in acute myeloid leukemia (AML)
Universitätsklinikum Ulm am Oberen Eselsberg
Klinik für Innere Medizin III

Baden-Württemberg
ULM
Design and Evaluation of Real-Time RT-PCR Assays for the Detection of Minimal Residual Disease in AML
Universitätsklinikum Ulm am Oberen Eselsberg
Klinik für Innere Medizin III

Baden-Württemberg
ULM
Molecular Genetic and Functional Characterization of Candidate Genes Located in the Commonly Deleted Region at Chromosomal Bands 7q22-q31 in Myeloid Leukemias
Universitätsklinikum Ulm am Oberen Eselsberg
Klinik für Innere Medizin III

Hessen
MARBURG
A synthetic lethal screen to identify novel targets for therapy in acute myeloid leukemia
Universitätsklinikum Gießen und Marburg GmbH, Standort Marburg
Klinik für Innere Medizin - Schwerpunkt Hämatologie, Onkologie und Immunologie

Hessen
MARBURG
Epigenetics of the nuclear oncogene Ski in AML (SPP 1463: Epigenetic regulation of normal hematopoiesis and its dysregulation in myeloid neoplasia)
Universitätsklinikum Gießen und Marburg GmbH, Standort Marburg
Klinik für Innere Medizin - Schwerpunkt Hämatologie, Onkologie und Immunologie

Hessen
MARBURG
Cooperation of Ras induced signaling and the nuclear oncogene Ski in acute myeloid leukemia (AML) and malignant melanoma (TRR 17: Ras-dependent pathways in human cancer)
Universitätsklinikum Gießen und Marburg GmbH, Standort Marburg
Klinik für Innere Medizin - Schwerpunkt Hämatologie, Onkologie und Immunologie

Niedersachsen
HANNOVER
AML-BFM Registry 2012: Clinical registry for children and adolescents with acute myeloid leukemia
KPOH Geschäftsführung Hannover
Kompetenznetz Pädiatrische Onkologie und Hämatologie

Niedersachsen
HANNOVER
Signal transduction of c-Kit and c-Kit related tyrosine kinases: mRNA export and hematopoesis
Medizinische Hochschule Hannover
Institut für Physiologische Chemie

Niedersachsen
HANNOVER
The histamine H2-receptor as new target for differentiation therapy in acute myeloic leukemia
Medizinische Hochschule Hannover
Institut für Pharmakologie

Nordrhein-Westfalen
ESSEN
AML-BFM Registry 2012: Clinical registry for children and adolescents with acute myeloid leukemia
Universitätsklinikum Essen
Klinik für Kinderheilkunde III - Abteilung für pädiatrische Hämatologie und Onkologie

Sachsen
DRESDEN
ALLIVE (ALLogeneic Iron inVEstigators) Observational Trial: Assessment of body, liver and labile plasma iron and their association with outcome and immunological recovery in Myelodysplastic syndromes or Acute Myeloid Leukemia patients undergoing allogeneic stem cell transplantation
Universitätsklinikum Carl Gustav Carus an der TU Dresden
Medizinische Klinik und Poliklinik I

Sachsen
DRESDEN
AML Registry: Clinical AML Registry
Universitätsklinikum Carl Gustav Carus an der TU Dresden
SAL-Studienzentrale

Poznan
POZNAN
Assessment of treatment effectiveness in childhood acute lymphoblastic leukaemia by monitoring minimal residual disease with 8-color flow cytometry
Instytut Genetyki Czlowieka - Institute of Human Genetics

Canarias
LAS PALMAS
Implication of the epigenetic regulators BRD4, EZH2 and ASXL1 in acute myeloid leukemia
Hospital Universitario de Gran Canaria, Doctor Negrín
Servicio de Hematología

Cataluña
BARCELONA
Targeted therapy of Auristatin E or Ara-C to acute myeloid leukemia cells that express CXCR4, a receptor involved in stromal adhesion and chemoresistance
Hospital de la Santa Creu i Sant Pau
Servicio de Hematología

Comunidad Valenciana
VALENCIA
VILMA: Therapeutic Results in Acute Mieloblastic Leukemia in Patients Older Than 60 Years or Not Candidates for Intensive Chemotherapy - ES
Hospital Universitario y Politécnico La Fe
Servicio de Hematología y Hemoterapia

Madrid
MADRID
An integrated analysis system to increase the rate of diagnosis of rare diseases using massive sequencing
Fundación Jiménez Díaz
Área de Genética y Genómica

Navarra
PAMPLONA
Discovery and characterization of small-molecule activators of the tumor suppressor protein PP2A for the treatment of acute myeloid leukemia
CIMA - Centro de Investigación Médica Aplicada
Programa de Tumores sólidos y biomarcadores

Stockholms läns landsting
HUDDINGE
Molecular pathogenesis in myelodysplastic syndromes and acute myeloid leukemia
Karolinska Institutet - Huddinge
Department of Medicine

Stockholms läns landsting
STOCKHOLM
Study of chemotherapy resistance and DNA methylation in acute myeloid leukemia samples
Karolinska University Hospital - Huddinge
Hematology Centre

ILE-DE-FRANCE
VILLEJUIF
ENCCA: EUROPEAN NETWORK for CANCER research in CHILDREN and ADOLESCENTS - FR
CLCC Institut Gustave Roussy
Département de cancérologie de l'enfant et de l'adolescent

CAMPANIA
NAPOLI
Telethon Undiagnosed Disease Program - Revised Proposal
Azienda Ospedaliera Universitaria - Seconda Università degli Studi di Napoli
Laboratorio di Genetica Medica

ILE-DE-FRANCE
ORSAY
DCD-CANC-CHILD: design of drug carrier and delivery control for cancer therapy of children
Université Paris-Sud
Institut de Chimie Moléculaire et des Matériaux d'Orsay

LOMBARDIA
MILANO
RARECARE: surveillance of rare cancers in Europe (coordination)
Fondazione IRCCS Istituto Nazionale dei Tumori
S.S. di Epidemiologia Valutativa

Tyne & Wear
NEWCASTLE UPON TYNE
EPOC: European paediatric oncology off-patent medicines consortium (coordination)
Northern Institute for Cancer Research, Medical School, Newcastle University
Northern Institute for Cancer Research
Multicentric Research projects
- Universitätsklinikum Mannheim
- European Leukemia Net - Network Management Center
- Universitätsklinikum Mannheim
- European Leukemia Net - Network Management Center
- Otto-Heubner-Centrum für Kinder- und Jugendmedizin
- Klinik für Pädiatrie mit Schwerpunkt Endokrinologie, Gastroenterologie und Stoffwechselmedizin
- St. Anna Kinderkrebsforschung
- Children's Cancer Research Institute
- University of British Columbia
- Maternal Infant Child and Youth Research Network
- IRCCS Ospedale Pediatrico Bambino Gesù - SEDE GIANICOLO
- Servizio Clinico di Consulenza Genetica
- St. Anna Kinderkrebsforschung
- Children's Cancer Research Institute
- Universitätsklinik für Kinder- und Jugendmedizin Tübingen
- Abteilung für allgemeine Pädiatrie, Hämatologie/Onkologie
- Otto-Heubner-Centrum für Kinder- und Jugendmedizin
- Klinik für Pädiatrie mit Schwerpunkt Onkologie und Hämatologie
- Klinikum Dortmund gGmbH - Klinikzentrum Mitte
- Klinik für Kinder- und Jugendmedizin
- Fondazione IRCCS Istituto Nazionale dei Tumori
- S.S. di Epidemiologia Valutativa
- Fondazione IRCCS Istituto Nazionale dei Tumori
- S.S. di Epidemiologia Valutativa
- University Hospital of Wales
- Department of Haematology
- Northern Institute for Cancer Research, Medical School, Newcastle University
- Northern Institute for Cancer Research
- Institut Curie
- Macromolécules et Microsystèmes en Biologie et en Medecine

Baden-Württemberg
MANNHEIM
Competence Network 'acute and chronic leukemias'

Baden-Württemberg
MANNHEIM
EUROPEAN LEUKEMIA NET: Strengthen and develop scientific and technological excellence in research and therapy of leukemia

Berlin
BERLIN
NGFN plus: Leukemia Network - functional and translational studies on acute lymphoblastic leukemia in childhood -terminated

WIEN
WIEN
ENCCA: EUROPEAN NETWORK for CANCER research in CHILDREN and ADOLESCENTS

Colombie-Britannique
VANCOUVER
Maternal Infant Child and Youth Research Network (MICYRN)

LAZIO
ROMA
UnRareNet: a muticenter collaborative research network for the identification and study of rare undiagnosed patients (completed)

WIEN
WIEN
DIRECT: disseminate research funded by EC improving treatment options for children suffering from cancer

Baden-Württemberg
TÜBINGEN
Information network for rare tumors in children and adolescents

Berlin
BERLIN
Competence Network Paediatric Oncology and Haematology (Research)

Nordrhein-Westfalen
DORTMUND
Information network for rare tumors in children and adolescents

LOMBARDIA
MILANO
RARECARE: surveillance of rare cancers in Europe

LOMBARDIA
MILANO
RARECARENet: Network informativo sui tumori rari

South Glamorgan
CARDIFF
South East Wales Cancer Network

Tyne & Wear
NEWCASTLE UPON TYNE
EPOC: European paediatric oncology off-patent medicines consortium

ILE-DE-FRANCE
ORSAY