Search for a gene
SNCA - synuclein alpha
- Synonym(s) : α-synuclein, alpha-synuclein, a-synuclein, NACP, non A4 component of amyloid precursor, PD1
- Previous symbols and names : PARK1, PARK4, Parkinson disease (autosomal dominant, Lewy body) 4, synuclein, alpha (non A4 component of amyloid precursor)
- Type : gene with protein product
- Chromosomal location : 4q22.1
- OMIM: 163890
- HGNC: 11138
- UniProtKB: P37840
- Genatlas: SNCA
- GenCC: SNCA
- Ensembl: ENSG00000145335
- IUPHAR-DB: -
- Reactome: P37840
- LOVD: SNCA
Diseases list
- Disease-causing germline mutation(s) in Parkinsonian-pyramidal syndrome
ORPHA:171695 
- Disease-causing germline mutation(s) (gain of function) in Hereditary late-onset Parkinson disease
ORPHA:411602 - Major susceptibility factor in NON RARE IN EUROPE: Dementia with Lewy body
ORPHA:1648 - Candidate gene tested in Young-onset Parkinson disease
ORPHA:2828
: AssessedAdditional information
Patient-centred resources for this gene
Research activities on this gene
Specialised Social Services
The documents contained in this web site are presented for information purposes only. The material is in no way intended to replace professional medical care by a qualified specialist and should not be used as a basis for diagnosis or treatment.
Orphanet is part of the Gene Curation Coalition, a global effort to harmonise gene-level resources.