Clinical Signs and Symptoms

* (*) mandatory field

ORPHA:43393  Lambert-Eaton myasthenic syndrome

The phenotypic description of this disease is based on an analysis of the biomedical literature and uses the terms of the Human Phenotype Ontology (HPO). Phenotypic abnormalities are presented by order of frequency of occurrence in the patient population, then by alphabetical order inside each frequency group.

Diagnostic criterion *
Progressive proximal muscle weakness HP:0009073
Reduced tendon reflexes HP:0001315
* Phenotypic abnormalities noted as « diagnostic criterion » are those included in established sets of criteria to establish the diagnosis of a particular disease having been published in a peer-reviewed journal.
Clinical signs and symptoms

    Very frequent

  • Calcium channel antibody positivity HP:0030209
  • Dysautonomia HP:0002459
  • EMG: decremental response of compound muscle action potential to repetitive nerve stimulation HP:0003403
  • EMG: repetitive nerve stimulation abnormality HP:0030000
  • Progressive proximal muscle weakness HP:0009073
  • Reduced tendon reflexes HP:0001315
  • Xerostomia HP:0000217

Additional information

Specialised Social Services


The information provided is based on published scientific articles.

The information provided is estimated for the entire population of patients in routine care. Some phenotypic abnormalities reported here may occur individually with a variable temporality or severity, while others, not listed, may still be encountered. Phenotypic annotations are not yet available for all rare diseases; the annotation process is ongoing.

The information contained in Orphanet is regularly updated. It is possible that discoveries have been made since the last update and have not yet been incorporated.

Professionals are encouraged to always consult the latest scientific publications before making a decision based on the information provided. The information contained in Orphanet is not intended to replace the services of a healthcare professional. Orphanet cannot be held responsible for the deleterious, truncated or erroneous use of any information found in the Orphanet database.