Orphanet: Clinical Signs and Symptoms

Clinical Signs and Symptoms

ORPHA:83597 Acute disseminated encephalomyelitis

The phenotypic description of this disease is based on an analysis of the biomedical literature and uses the terms of the Human Phenotype Ontology (HPO). Phenotypic abnormalities are presented by order of frequency of occurrence in the patient population, then by alphabetical order inside each frequency group.

Diagnostic criterion *

Encephalopathy HP:0001298

* Phenotypic abnormalities noted as « diagnostic criterion » are those included in established sets of criteria to establish the diagnosis of a particular disease having been published in a peer-reviewed journal.

Clinical signs and symptoms

Always present

Encephalopathy HP:0001298

Very frequent

CNS demyelination HP:0007305
Diffuse white matter abnormalities HP:0007204
EEG with generalized slow activity HP:0010845

Frequent

Abnormal brainstem MRI signal intensity HP:0012747
Abnormal cerebellum morphology HP:0001317
Abnormal pyramidal sign HP:0007256
Abnormal thalamic MRI signal intensity HP:0012696
Abnormality of the basal ganglia HP:0002134
Abnormality of the periventricular white matter HP:0002518
Abnormality of the spinal cord HP:0002143
Anti-myelin oligodendrocyte glycoprotein antibody positivity HP:0032492
Ataxia HP:0001251
Behavioral abnormality HP:0000708
CSF lymphocytic pleiocytosis HP:0200149
Cerebral edema HP:0002181
Disseminated viral infection HP:0031696
Fever HP:0001945
Headache HP:0002315
Hypersomnia HP:0100786
Increased CSF protein HP:0002922
Interictal EEG abnormality HP:0025373
Irritability HP:0000737
Mental deterioration HP:0001268
Myelitis HP:0012486
Nausea HP:0002018
Seizures HP:0001250

Occasional

Aggressive behavior HP:0000718
Coma HP:0001259
Confusion HP:0001289
Cranial nerve paralysis HP:0006824
EEG with focal slow activity HP:0010843
EEG with focal spikes HP:0011193
Eye movement-induced pain HP:0030857
Hemiparesis HP:0001269
Muscle weakness HP:0001324
Neurological speech impairment HP:0002167
Nuchal rigidity HP:0031179
Obtundation status HP:0011151
Optic neuritis HP:0100653
Respiratory failure requiring assisted ventilation HP:0004887
Sensory impairment HP:0003474
Visual loss HP:0000572
Vomiting HP:0002013

Rare

Diaphragmatic paralysis HP:0006597
Herpes simplex encephalitis HP:0012302
Hypointensity of cerebral white matter on MRI HP:0007103
Involuntary movements HP:0004305
Post-vaccination measles HP:0020088
Post-vaccination rubella HP:0020089
Severe Epstein Barr virus infection HP:0031693
Severe parainfluenza infection HP:0031695
Viral hepatitis HP:0006562

Additional information

Further information

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Warning

The information provided is based on published scientific articles.

The information provided is estimated for the entire population of patients in routine care. Some phenotypic abnormalities reported here may occur individually with a variable temporality or severity, while others, not listed, may still be encountered. Phenotypic annotations are not yet available for all rare diseases; the annotation process is ongoing.

The information contained in Orphanet is regularly updated. It is possible that discoveries have been made since the last update and have not yet been incorporated.

Professionals are encouraged to always consult the latest scientific publications before making a decision based on the information provided. The information contained in Orphanet is not intended to replace the services of a healthcare professional. Orphanet cannot be held responsible for the deleterious, truncated or erroneous use of any information found in the Orphanet database.