Clinical Signs and Symptoms
ORPHA:90695 Non-acquired panhypopituitarism
The phenotypic description of this disease is based on an analysis of the biomedical literature and uses the terms of the Human Phenotype Ontology (HPO). Phenotypic abnormalities are presented by order of frequency of occurrence in the patient population, then by alphabetical order inside each frequency group.
- Hypopituitarism HP:0040075
Always present
- Abnormal prolactin level HP:0040086
- Abnormality of secondary sexual hair HP:0009888
- Amenorrhea HP:0000141
- Anterior pituitary hypoplasia HP:0010627
- Aplasia/Hypoplasia of the breasts HP:0010311
- Decreased circulating ACTH level HP:0002920
- Decreased testicular size HP:0008734
- Depressed nasal ridge HP:0000457
- Fatigue HP:0012378
- Growth delay HP:0001510
- Growth hormone deficiency HP:0000824
- Hypoglycemia HP:0001943
- Hypogonadotrophic hypogonadism HP:0000044
- Hypotension HP:0002615
- Infertility HP:0000789
- Pituitary hypothyroidism HP:0008245
- Short stature HP:0004322
Frequent
- Absence of secondary sex characteristics HP:0008187
- Constipation HP:0002019
- Delayed puberty HP:0000823
- Delayed skeletal maturation HP:0002750
- Osteopenia HP:0000938
- Osteoporosis of vertebrae HP:0005625
- Pituitary dwarfism HP:0000839
Occasional
- Ectopic anterior pituitary gland HP:0012731
- Ectopic posterior pituitary HP:0011755
Rare
Additional information
Further information
Specialised Social Services
Warning
The information provided is based on published scientific articles.
The information provided is estimated for the entire population of patients in routine care. Some phenotypic abnormalities reported here may occur individually with a variable temporality or severity, while others, not listed, may still be encountered. Phenotypic annotations are not yet available for all rare diseases; the annotation process is ongoing.
The information contained in Orphanet is regularly updated. It is possible that discoveries have been made since the last update and have not yet been incorporated.
Professionals are encouraged to always consult the latest scientific publications before making a decision based on the information provided. The information contained in Orphanet is not intended to replace the services of a healthcare professional. Orphanet cannot be held responsible for the deleterious, truncated or erroneous use of any information found in the Orphanet database.