Orphanet: Clinical Signs and Symptoms

Clinical Signs and Symptoms

ORPHA:101016 Romano-Ward syndrome

The phenotypic description of this disease is based on an analysis of the biomedical literature and uses the terms of the Human Phenotype Ontology (HPO). Phenotypic abnormalities are presented by order of frequency of occurrence in the patient population, then by alphabetical order inside each frequency group.

Diagnostic criterion *

Prolonged QTc interval HP:0005184

* Phenotypic abnormalities noted as « diagnostic criterion » are those included in established sets of criteria to establish the diagnosis of a particular disease having been published in a peer-reviewed journal.

Clinical signs and symptoms

Always present

Prolonged QTc interval HP:0005184

Frequent

Abnormal T-wave HP:0005135
Sinus bradycardia HP:0001688
Syncope HP:0001279

Occasional

Abnormal autonomic nervous system physiology HP:0012332
Abnormal cardiac exercise stress test HP:0500018
Seizure HP:0001250
Sudden cardiac death HP:0001645
Torsade de pointes HP:0001664
Ventricular arrhythmia HP:0004308

Rare

Abnormality of prenatal development or birth HP:0001197
Hypokalemia HP:0002900

Exclusion criterion *

Hearing impairment HP:0000365

* Phenotypic abnormalities noted as « exclusion criterion » are those that are always absent in a particular disease and therefore exclude its diagnosis.

Additional information

Further information

Specialised Social Services

Eurordis directory

Warning

The information provided is based on published scientific articles.

The information provided is estimated for the entire population of patients in routine care. Some phenotypic abnormalities reported here may occur individually with a variable temporality or severity, while others, not listed, may still be encountered. Phenotypic annotations are not yet available for all rare diseases; the annotation process is ongoing.

The information contained in Orphanet is regularly updated. It is possible that discoveries have been made since the last update and have not yet been incorporated.

Professionals are encouraged to always consult the latest scientific publications before making a decision based on the information provided. The information contained in Orphanet is not intended to replace the services of a healthcare professional. Orphanet cannot be held responsible for the deleterious, truncated or erroneous use of any information found in the Orphanet database.