Clinical Signs and Symptoms
ORPHA:683 Progressive supranuclear palsy
The phenotypic description of this disease is based on an analysis of the biomedical literature and uses the terms of the Human Phenotype Ontology (HPO). Phenotypic abnormalities are presented by order of frequency of occurrence in the patient population, then by alphabetical order inside each frequency group.
- Abnormal synaptic transmission HP:0012535
- Dysphagia HP:0002015
- Falls HP:0002527
- Impulsivity HP:0100710
- Neuronal loss in central nervous system HP:0002529
- Postural instability HP:0002172
- Supranuclear gaze palsy HP:0000605
- Supranuclear ophthalmoplegia HP:0000623
- Unsteady gait HP:0002317
Very frequent
- Aphasia HP:0002381
- Blepharospasm HP:0000643
- Bradykinesia HP:0002067
- Cerebral cortical atrophy HP:0002120
- Cognitive impairment HP:0100543
- Delayed speech and language development HP:0000750
- Depressivity HP:0000716
- Dystonia HP:0001332
- Gliosis HP:0002171
- Memory impairment HP:0002354
- Pseudobulbar signs HP:0002200
- Slow saccadic eye movements HP:0000514
- Vertical supranuclear gaze palsy HP:0000511
Frequent
- Abnormality of eye movement HP:0000496
- Dementia HP:0000726
- Rigidity HP:0002063
- Tremor HP:0001337
Occasional
Additional information
Further information
Specialised Social Services
Warning
The information provided is based on published scientific articles.
The information provided is estimated for the entire population of patients in routine care. Some phenotypic abnormalities reported here may occur individually with a variable temporality or severity, while others, not listed, may still be encountered. Phenotypic annotations are not yet available for all rare diseases; the annotation process is ongoing.
The information contained in Orphanet is regularly updated. It is possible that discoveries have been made since the last update and have not yet been incorporated.
Professionals are encouraged to always consult the latest scientific publications before making a decision based on the information provided. The information contained in Orphanet is not intended to replace the services of a healthcare professional. Orphanet cannot be held responsible for the deleterious, truncated or erroneous use of any information found in the Orphanet database.