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Generalized arterial calcification of infancy

Disease definition

A rare genetic vascular disease characterized by early onset (between in utero to infancy) of extensive calcification and stenosis of the large and medium sized arteries. Presentation is typically with respiratory distress, congestive heart failure and systemic hypertension.


Classification level: Disorder
  • Synonym(s):
    • Idiopathic infantile arterial calcification
    • Idiopathic obliterative arteriopathy
    • Infantile arteriosclerosis
    • Occlusive infantile arteriopathy
  • Prevalence: Unknown
  • Inheritance: Autosomal dominant or Autosomal recessive 
  • Age of onset: Infancy, Neonatal, Antenatal
  • ICD-10: Q28.8
  • OMIM: 208000  614473
  • UMLS: C0264955  C1859727
  • MeSH: C537440
  • GARD: 8380
  • MedDRA: -

Detailed information


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