Orphanet: Purpura thrombotique thrombocytopénique

Search for a rare disease

* (*) mandatory field

Other search option(s)

Suggest an update

(*) Required fields.


Only comments seeking to improve the quality and accuracy of information on the Orphanet website are accepted. For all other comments, please send your remarks via contact us. Only comments written in English can be processed.

Captcha image

Thrombotic thrombocytopenic purpura

Disease definition

An aggressive and life-threatening form of thrombotic microangiopathy (TMA) characterized by profound peripheral thrombocytopenia, microangiopathic hemolytic anemia (MAHA) and organ failure of variable severity and is comprised of a congenital (cTTP) and acquired, immune-mediated (iTTP) form.


Classification level: Disorder
  • Synonym(s):
    • Moschcowitz disease
    • TTP
  • Prevalence: 1-5 / 10 000
  • Inheritance: Autosomal recessive or Multigenic/multifactorial 
  • Age of onset: All ages
  • ICD-10: M31.1
  • OMIM: 274150
  • UMLS: C0034155
  • MeSH: D011697
  • GARD: -
  • MedDRA: 10043648

Detailed information

Article for general public


The documents contained in this web site are presented for information purposes only. The material is in no way intended to replace professional medical care by a qualified specialist and should not be used as a basis for diagnosis or treatment.