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McLeod neuroacanthocytosis syndrome

Disease definition

McLeod neuroacanthocytosis syndrome (MLS) is a form of neuroacanthocytosis (see this term) and is characterized clinically by a Huntington's disease-like phenotype with an involuntary hyperkinetic movement disorder, psychiatric manifestations and cognitive alterations, and biochemically by absence of the Kx antigen and by weak expression of the Kell antigens.


Classification level: Disorder
  • Synonym(s):
    • MLS
    • X-linked McLeod syndrome
  • Prevalence: <1 / 1 000 000
  • Inheritance: X-linked recessive 
  • Age of onset: Adult
  • ICD-10: G10
  • OMIM: 300842
  • UMLS: C0398568
  • MeSH: -
  • GARD: 10731
  • MedDRA: -

Detailed information


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