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Growth delay due to insulin-like growth factor I resistance

Disease definition

Growth delay due to IGF-I resistance is characterised by variable intrauterine and postnatal growth retardation and elevated serum IGF-I levels. Addition features include variable degrees of intellectual deficit, microcephaly and dysmorphism (broad nasal bridge and tip, smooth philtrum, thin upper and everted lower lips, short fingers, clinodactyly, wide-set nipples and pectus excavatum).

ORPHA:73273

  • Synonym(s):
    • Resistance to IGF-1
  • Prevalence: Unknown
  • Inheritance: Autosomal dominant or Autosomal recessive 
  • Age of onset: Infancy, Neonatal
  • ICD-10: E34.3
  • OMIM: 270450
  • UMLS: C1849157
  • MeSH: -
  • GARD: 10609
  • MedDRA: -
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