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Acute liver failure

Disease definition

A rare hepatic disease characterized by acute onset of severe liver dysfunction without evidence of underlying chronic liver disease. Patients present with nonspecific symptoms like jaundice, upper right abdominal pain, nausea, vomiting, pruritus, fatigue, and fever. The condition may rapidly progress to hepatic encephalopathy, coagulopathy, and life-threatening multiorgan failure. Liver biopsy typically shows massive hepatic necrosis.


Classification level: Disorder
  • Synonym(s):
    • Acute hepatic failure
    • Fulminant hepatic failure
  • Prevalence: 1-5 / 10 000
  • Inheritance: Not applicable 
  • Age of onset: -
  • ICD-10: K72.0
  • OMIM: -
  • UMLS: C0162557
  • MeSH: D017114
  • GARD: -
  • MedDRA: 10000804
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