Orphanet: Purpura thrombotique thrombocytopénique acquis

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Immune-mediated thrombotic thrombocytopenic purpura

Disease definition

A rare, non-hereditary thrombotic thrombocytopenic purpura (TTP), characterized by profound peripheral thrombocytopenia, microangiopathic hemolytic anemia (MAHA) and single or multiple organ failure of variable severity.


Classification level: Subtype of disorder
  • Synonym(s):
    • Acquired TTP
    • Acquired thrombotic thrombocytopenic purpura
    • Autoimmune thrombotic thrombocytopenic purpura
    • Thrombotic thrombocytopenic purpura due to anti-ADAMTS-13 antibodies
    • aTTP
    • iTTP
  • Prevalence: Unknown
  • Inheritance: Multigenic/multifactorial 
  • Age of onset: All ages
  • ICD-10: M31.1
  • OMIM: -
  • UMLS: C2584778
  • MeSH: C536901
  • GARD: -
  • MedDRA: -

Detailed information


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