Search for a rare disease

* (*) mandatory field

Other search option(s)

Suggest an update

(*) Required fields.


Only comments seeking to improve the quality and accuracy of information on the Orphanet website are accepted. For all other comments, please send your remarks via contact us. Only comments written in English can be processed.

Captcha image

Reis-Bücklers corneal dystrophy

Disease definition

Reis-Bücklers corneal dystrophy (RBCD), also known as granular corneal dystrophy type III, is a rare form of superficial corneal dystrophy characterized by bilateral symmetrical reticular opacities in the superficial central cornea, with progressive visual impairment.


  • Synonym(s):
    • Anterior limiting membrane dystrophy type 1
    • Anterior limiting membrane dystrophy type I
    • Atypical granular corneal dystrophy
    • Corneal dystrophy of Bowman layer type 1
    • Corneal dystrophy of Bowman layer type I
    • Geographic corneal dystrophy
    • Granular corneal dystrophy type 3
    • Granular corneal dystrophy type III
    • RBCD
    • Superficial granular corneal dystrophy
  • Prevalence: <1 / 1 000 000
  • Inheritance: Autosomal dominant 
  • Age of onset: Childhood
  • ICD-10: H18.5
  • OMIM: 608470
  • UMLS: C0339278
  • MeSH: C535476
  • GARD: 9276
  • MedDRA: -

Detailed information


Additional information

Further information on this disease

Specialised Social Services

The documents contained in this web site are presented for information purposes only. The material is in no way intended to replace professional medical care by a qualified specialist and should not be used as a basis for diagnosis or treatment.