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Lethal ataxia with deafness and optic atrophy
Lethal ataxia with deafness and optic atrophy (also known as Arts syndrome) is characterized by intellectual deficit, early-onset hypotonia, ataxia, delayed motor development, hearing impairment and loss of vision due to optic atrophy.
ORPHA:1187Classification level: Disorder
It was initially described in 12 male members from five generations of a Dutch family. Arts syndrome has also been described in one Australian family.
Other manifestations included floppiness, susceptibility to infections, and later, flaccid tetraplegia and areflexia.
It is caused by missense mutations in the phosphoribosyl pyrophosphate synthetase 1 gene (PRPS1) localized to Xq22.1-q24, leading to impaired purine biosynthesis.
Arts syndrome is transmitted as an X-linked recessive trait.
Management and treatment
Treatment with S-adenosylmethionine may be beneficial and is currently under evaluation.
The disease has a fatal course during childhood (the majority of patients die before the age of 5 years) due to the high susceptibility of the patients to infections, especially of the upper respiratory tract.
- Clinical genetics review
- English (2018)