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Autosomal dominant spastic paraplegia type 12

Disease definition

Autosomal dominant spastic paraplegia type 12 is a pure form of hereditary spastic paraplegia characterized by a childhood- to adulthood-onset of slowly progressive lower limb spasticity and hyperreflexia of lower extremities, extensor plantar reflexes, distal sensory impairment, variable urinary dysfunction and pes cavus.


  • Synonym(s):
    • SPG12
  • Prevalence: <1 / 1 000 000
  • Inheritance: Autosomal dominant 
  • Age of onset: Childhood, Adolescent, Adult
  • ICD-10: G11.4
  • OMIM: 604805
  • UMLS: C1858106
  • MeSH: C537484
  • GARD: 9586
  • MedDRA: -

Detailed information

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Additional information

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