Orphanet: Leucemia mielóide aguda e síndromes mielodisplásticos relacionados inibidores das topoisomerases tipo II
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Acute myeloid leukemia and myelodysplastic syndromes related to topoisomerase type 2 inhibitor

Disease definition

A subgroup of therapy-related myeloid neoplasms (t-MN), associated with treatment of an unrelated neoplastic disease with cytotoxic agents, like etoposid, doxorubicin, daunorubicin and others. The neoplastic cells often show rearrangements involving the mixed lineage leukemia gene at 11q23. This subgroup of t-MN is typically associated with overt leukemia, without preceding myelodysplastic syndrome, developing 2-3 years after exposure, presenting with non-specific symptoms related to ineffective hematopoesis (fatigue, bleeding and bruising, recurrent infections, bone pain) and/or extramedullary site involvement.

ORPHA:102381

Classification level: Disorder
  • Synonym(s):
    • AML and myelodysplastic syndromes related to topoisomerase type 2 inhibitor
  • Prevalence: -
  • Inheritance: -
  • Age of onset: -
  • ICD-10: C92.0
  • OMIM: -
  • UMLS: -
  • MeSH: -
  • GARD: -
  • MedDRA: -

Detailed information

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