Orphanet: Cooks syndrome

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Cooks syndrome

Disease definition

Cooks syndrome is a malformation syndrome affecting the apical structures of digits and presenting with hypo/aplasia of nails and distal phalanges. More than half of digits are usually involved and the thumbs may appear digitalized.


Classification level: Disorder
  • Synonym(s):
    • Anonychia-onychodystrophy with hypoplasia or absence of distal phalanges syndrome
    • ODP
  • Prevalence: <1 / 1 000 000
  • Inheritance: Autosomal dominant 
  • Age of onset: Neonatal
  • ICD-10: Q84.6
  • OMIM: 106995
  • UMLS: C1862841
  • MeSH: -
  • GARD: 4083
  • MedDRA: -

Detailed information


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