Orphanet: Limbic encephalitis with NMDA receptor antibodies
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Limbic encephalitis with NMDA receptor antibodies

Disease definition

A rare limbic encephalitis characterized by the presence of autoantibodies against NMDA receptors in serum and cerebrospinal fluid. It may be of paraneoplastic (most commonly associated with ovarian teratoma) or non-paraneoplastic origin and is life-threatening but potentially treatable. Patients present with acute behavioral change, psychosis, and catatonia, rapidly progressing to seizures, memory deficit, dyskinesias, speech problems, and autonomic and breathing dysregulation.

ORPHA:217253

Classification level: Disorder
  • Synonym(s):
    • Limbic encephalitis with N-methyl-D-aspartate receptor antibodies
  • Prevalence: Unknown
  • Inheritance: Not applicable 
  • Age of onset: All ages
  • ICD-10: G13.1
  • OMIM: -
  • UMLS: -
  • MeSH: -
  • GARD: -
  • MedDRA: -

Detailed information

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