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Semilobar holoprosencephaly is one of the classical forms of holoprosencephaly (HPE; see this term) in which the left and right frontal and parietal lobes are fused and the interhemispheric fissure is only present posteriorly.
ORPHA:220386Classification level: Subtype of disorder
About 28% to 54% of HPE patients have semilobar type.
Significant clinical variability and genetic complexity underlie HPE.