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Non-syndromic male infertility due to sperm motility disorder

Disease definition

Non-syndromic male infertility due to sperm motility disorder is a rare, genetic, non-syndromic male infertility disorder characterized by infertility due to sperm with defects in their cilia/flagella structure, leading to absent motility or reduced forward motility in fresh ejaculate. Reduced semen volume, oligospermia and an increased number of abnormally structured spermatozoa is often present.


  • Synonym(s):
    • Non-syndromic male infertility due asthenozoospermia
  • Prevalence: Unknown
  • Inheritance: Autosomal recessive 
  • Age of onset: Adult
  • ICD-10: N46
  • OMIM: 606766  612997  614822  617576  617592  617593  617965  618152  618153
  • UMLS: -
  • MeSH: -
  • GARD: -
  • MedDRA: -

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