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Infantile-onset ascending hereditary spastic paralysis

Disease definition

Infantile-onset ascending hereditary spastic paralysis (IAHSP) is a very rare motor neuron disease characterized by severe spasticity of the lower limbs in early life, progression of spasticity to the upper limbs in late childhood, and dysarthria.

ORPHA:293168

  • Synonym(s):
    • IAHSP
  • Prevalence: <1 / 1 000 000
  • Inheritance: Autosomal recessive 
  • Age of onset: Infancy, Neonatal
  • ICD-10: G12.2
  • OMIM: 607225
  • UMLS: C2931441
  • MeSH: -
  • GARD: 4914
  • MedDRA: -

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