Orphanet: Malignant migrating focal seizures of infancy

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Malignant migrating focal seizures of infancy

Disease definition

A rare, genetic, neonatal epilepsy syndrome disease characterized by onset in the first 6 months of life of almost continuous migrating polymorphous focal seizures with corresponding multifocal ictal electroencephalographic discharges, progressive deterioration of psychomotor development, and usually early mortality.


Classification level: Disorder
  • Synonym(s):
    • Epilepsy of infancy with migrating focal seizures
    • MMPEI
    • MMPSI
    • MPEI
    • MPSI
    • Malignant migrating partial epilepsy of infancy
    • Malignant migrating partial seizures of infancy
    • Migrating partial epilepsy of infancy
    • Migrating partial seizures of infancy
  • Prevalence: <1 / 1 000 000
  • Inheritance: Autosomal dominant or Autosomal recessive 
  • Age of onset: Infancy, Neonatal
  • ICD-10: -
  • OMIM: 613722  614959  615338  616645
  • UMLS: -
  • MeSH: -
  • GARD: 12919
  • MedDRA: -

Detailed information


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