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MiT family translocation renal cell carcinoma

Disease definition

MiT family translocation renal cell carcinoma (t-RCC) is a rare subtype of renal cell carcinoma with recurrent genetic abnormalities, harboring rearrangements of the TFE3 (Xp11 t-RCC) or TFEB [t(6;11) t-RCC] genes. The t(6;11) t-RCC has distinctive histologic features of biphasic appearance with larger epitheloid and smaller eosinophilic cells. The symptoms are usually non-specific and include hematuria, flank pain, palpable abdominal mass and/or systemic symptoms of anemia, fatigue and fever.

ORPHA:319308

  • Synonym(s):
    • Carcinoma associated with MITF/TFE translocation
    • Translocation renal cell carcinoma
  • Prevalence: -
  • Inheritance: -
  • Age of onset: Infancy, Childhood, Adolescent, Adult, Elderly
  • ICD-10: C64
  • OMIM: 300854
  • UMLS: -
  • MeSH: -
  • GARD: -
  • MedDRA: -

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