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ABetaA21G amyloidosis

Disease definition

A form of hereditary cerebral hemorrhage with amyloidosis characterized by an age of onset of 45 years of age, progressive Alzheimer's disease-like dementia, and lobar intracerebral hemorrhage in some patients. This subtype is due to a mutation in the APP gene (21q21.2), encoding the beta-amyloid precursor protein. This mutation causes an increased accumulation of amyloid-beta protein in the walls of the arteries and capillaries of the meninges, cerebellar cortex and cerebral cortex, leading to the weakening and eventual rupture of these vessels.

ORPHA:324718

Classification level: Subtype of disorder
  • Synonym(s):
    • ABeta amyloidosis, Flemish type
    • ABetaA21G-related amyloidosis
    • HCHWA, Flemish type
    • Hereditary cerebral hemorrhage with amyloidosis, Flemish type
  • Prevalence: <1 / 1 000 000
  • Inheritance: Autosomal dominant 
  • Age of onset: Adult
  • ICD-10: E85.4+  I68.0*
  • OMIM: 605714
  • UMLS: -
  • MeSH: -
  • GARD: -
  • MedDRA: -

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