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ALK-positive large B-cell lymphoma

Disease definition

Anaplastic lymphoma kinase (ALK)-positive diffuse large B-cell lymphoma is a very rare variant of diffuse large B-cell lymphoma (DLBCL; see this term) mainly affecting middle-aged immunocompetent men and characterized by a consistent primary involvement of lymph nodes (mainly in the cervical and mediastinum lymph nodes) and with infrequent extra nodal involvement of the bone marrow and other extra-nodal sites (head and neck region, liver, spleen, and gastrointestinal tract). It has an aggressive disease course, and is associated with a poor prognosis.

ORPHA:364043

  • Synonym(s):
    • ALK+ LBCL
    • ALK+ large B-cell lymphoma
  • Prevalence: -
  • Inheritance: Not applicable or Multigenic/multifactorial 
  • Age of onset: -
  • ICD-10: C83.3
  • OMIM: -
  • UMLS: -
  • MeSH: -
  • GARD: -
  • MedDRA: -

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