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Multicentric osteolysis-nodulosis-arthropathy spectrum

Disease definition

A rare systemic or rheumatologic disease characterized by peripheral osteolysis (especially carpal and tarsal bones), interphalangeal joint erosions, subcutaneous fibrocollagenous nodules, facial dysmorphism, and a wide range of associated manifestations.


Classification level: Disorder
  • Synonym(s):
    • MONA spectrum
    • NAO syndrome
    • Nodulosis-arthropathy-osteolysis syndrome
    • Torg-Winchester syndrome
  • Prevalence: Unknown
  • Inheritance: Autosomal recessive 
  • Age of onset: Infancy, Childhood
  • ICD-10: M89.5
  • OMIM: 259600  277950
  • UMLS: -
  • MeSH: -
  • GARD: -
  • MedDRA: -

Detailed information


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