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Primary immunodeficiency with post-measles-mumps-rubella vaccine viral infection

Disease definition

Primary immunodeficiency with post-measles-mumps-rubella vaccine viral infection is a rare primary immunodeficiency due to a defect in innate immunity disorder characterized by selective susceptibility to viral infections, particularly after systemic challenge with live viral vaccines, such as the measles, mumps and rubella (MMR) vaccine. Patients present severe, potentially fatal, manifestations to viral illness, including encephalitis, hepatitis and pneumonitis.


Classification level: Disorder
  • Synonym(s):
    • Primary immunodeficiency with post-MMR vaccine viral infection
  • Prevalence: <1 / 1 000 000
  • Inheritance: Autosomal recessive 
  • Age of onset: Infancy
  • ICD-10: D84.8
  • OMIM: 616636  616669
  • UMLS: -
  • MeSH: -
  • GARD: -
  • MedDRA: -
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