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Squamous cell carcinoma of the nasal cavity and paranasal sinuses

Disease definition

A rare head and neck tumor characterized by a malignant epithelial neoplasm most commonly arising in the maxillary sinus or nasal cavity, occurring as a keratinizing, a non-keratinizing, or a spindle cell (sarcomatoid) type. Patients may present with nasal obstruction, epistaxis, rhinorrhea, swelling, or (at more advances stages) with facial pain and/or paralysis, diplopia, and proptosis. Patients with paranasal sinus tumors present later and at a higher stage than patients with nasal cavity carcinomas. Risk factors are smoking and industrial exposures. High-risk HPV is most frequently associated with the non-keratinizing type.


Classification level: Disorder
  • Synonym(s):
    • Squamous cell carcinoma of the nasal cavity and sinuses
  • Prevalence: -
  • Inheritance: -
  • Age of onset: Adult, Elderly
  • ICD-10: -
  • OMIM: 275355
  • UMLS: -
  • MeSH: -
  • GARD: -
  • MedDRA: -
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