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Stevens-Johnson syndrome/toxic epidermal necrolysis overlap syndrome

Disease definition

An intermediate form of Stevens-Johnson syndrome/toxic epidermal necrolysis spectrum characterized by destruction and detachment of the skin epithelium, involving between 10 to 29% of the body surface area, and mucous membranes. Onset usually occurs 4-28 days after administration of the causal medication and is most frequently associated with anticonvulsants, antibacterial sulfonamides, allopurinol, nevirapine, and oxicams (non-steroidal anti-inflammatory drugs), but many other medications have also been implicated. The disease is not induced by medication in 15% of cases. Histology is characterized by an epidermal necrolysis. Multiple disabling long-term sequelae (especially cutaneous, ocular and psychological) are frequent.


Classification level: Subtype of disorder
  • Synonym(s):
    • SJS/TEN overlap syndrome
    • Stevens-Johnson/TEN overlap syndrome
    • Stevens-Johnson/toxic epidermal necrolysis overlap syndrome
  • Prevalence: -
  • Inheritance: -
  • Age of onset: -
  • ICD-10: L51.2
  • ICD-11: EB13.2
  • OMIM: -
  • UMLS: -
  • MeSH: -
  • GARD: -
  • MedDRA: -

Detailed information


ERN produced/endorsed by ERN(s)   FSMR produced/endorsed by FSMR(s)
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