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Tremor-nystagmus-duodenal ulcer syndrome

Disease definition

Tremor-nystagmus-duodenal ulcer syndrome is a rare hyperkinetic movement disorder characterized by mild to severe, progressive essential tremor, nystagmus (principally horizontal), duodenal ulceration and a narcolepsy-like sleep disturbance. Refractive errors and cerebellar signs, such as gait ataxia and adiadochokinesia, may be associated. There have been no further descriptions in the literature since 1976.


Classification level: Disorder
  • Synonym(s):
    • Neuhauser-Daly-Magnelli syndrome
  • Prevalence: <1 / 1 000 000
  • Inheritance: -
  • Age of onset: Neonatal
  • ICD-10: G25.0
  • OMIM: 190310
  • UMLS: C1860860
  • MeSH: -
  • GARD: 3948
  • MedDRA: -
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