Orphanet: Mischkollagenose

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Mixed connective tissue disease

Disease definition

Mixed connective tissue disease (MCTD) is a rare connective tissue disorder combining clinical features of systemic lupus erythematosus (SLE), systemic sclerosis (SSc), polymyositis (PM) (see these terms) and/or rheumatoid arthritis (RA).


Classification level: Disorder
  • Synonym(s):
    • MCTD
    • Sharp syndrome
  • Prevalence: 1-9 / 100 000
  • Inheritance: Multigenic/multifactorial 
  • Age of onset: Adolescent, Adult, Childhood
  • ICD-10: M35.1
  • OMIM: -
  • UMLS: C0026272
  • MeSH: D008947
  • GARD: 7051
  • MedDRA: 10027754

Detailed information

Article for general public


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