Orphanet: Wissler Fanconi Syndrom

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Adult-onset Still disease

Disease definition

A rare inflammatory multisystem disorder characterized clinically by four cardinal signs: fever of unknown origin, arthralgia or arthritis, hyperleucocytosis, and typical skin rash.


Classification level: Disorder
  • Synonym(s):
    • AOSD
    • Wissler-Fanconi syndrome
  • Prevalence: 1-9 / 100 000
  • Inheritance: Not applicable 
  • Age of onset: Elderly, Adult
  • ICD-10: M06.1
  • OMIM: -
  • UMLS: C0043195  C0085253
  • MeSH: D014924  D016706
  • GARD: 436
  • MedDRA: 10058493  10064056

Detailed information

Article for general public


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