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Locked-in syndrome

Disease definition

Locked-in syndrome (LIS) is a neurological condition characterized by the presence of sustained eye opening, quadriplegia or quadriparesis, anarthria, preserved cognitive functioning and a primary code of communication that uses vertical eye movements or blinking.


Classification level: Disorder
  • Synonym(s):
    • Cerebromedullospinal disconnection
  • Prevalence: <1 / 1 000 000
  • Inheritance: Not applicable 
  • Age of onset: All ages
  • ICD-10: G83.8
  • ICD-11: 8E45
  • OMIM: -
  • UMLS: C0023944
  • MeSH: D000080422
  • GARD: 6919
  • MedDRA: 10024792
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