Orphanet: Stiff person syndrome

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Stiff person spectrum disorder

Disease definition

A rare neurological disorder comprising fluctuating trunk and limb stiffness, painful muscle spasms, task-specific phobia, an exaggerated startle response, and ankylosing deformities such as fixed lumbar hyperlordosis.


Classification level: Disorder
  • Synonym(s):
    • Moersch-Woltman syndrome
    • SMS
    • SPS
    • Stiff man syndrome
  • Prevalence: 1-9 / 1 000 000
  • Inheritance: Not applicable 
  • Age of onset: Adult
  • ICD-10: G25.8
  • OMIM: 184850
  • UMLS: C0085292
  • MeSH: -
  • GARD: 5023
  • MedDRA: 10042044

Detailed information

Article for general public


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