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Acute promyelocytic leukemia

Disease definition

Acute promyelocytic leukemia (APL) is an aggressive form of acute myeloid leukemia (AML; see this term), characterized by arrest of leukocyte differentiation at the promyelocyte stage, due to a specific chromosomal translocation t(15;17) in myeloid cells. APL manifests with easy bruising, hemorrhagic diathesis and fatigue.


  • Synonym(s):
    • AML M3
    • AML with t(15;17)(q22;q12);(PML/RARalpha) and variants
    • APML
    • Acute myeloblastic leukemia 3
    • Acute myeloid leukemia with t(15;17)(q22;q12);(PML/RARalpha) and variants
  • Prevalence: Unknown
  • Inheritance: -
  • Age of onset: Adult
  • ICD-10: C92.4
  • OMIM: 612376
  • UMLS: C0023487
  • MeSH: D015473
  • GARD: 538
  • MedDRA: 10001019

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