Orphanet: Parathyroid carcinoma

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Parathyroid carcinoma

Disease definition

Parathyroid carcinoma (PRTC) is a very rare, slow-growing, clinically serious endocrine tumor that generally develops in mid-adulthood. PRTC presents as a palpable painless mass in the neck and causes severe hypercalcemia and related symptoms, non-specific gastrointestinal manifestations, as well as renal and bone complications related to primary hyperparathyroidism (nephrolithiasis, impaired renal function, osteoporosis, bone pain, and pathologic fractures, etc.). Some PRTCs are however non-functioning tumors.


Classification level: Disorder
  • Synonym(s): -
  • Prevalence: 1-9 / 1 000 000
  • Inheritance: -
  • Age of onset: Adult
  • ICD-10: C75.0
  • OMIM: 608266
  • UMLS: C0687150
  • MeSH: -
  • GARD: 7329
  • MedDRA: -

Detailed information


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