Search for a rare disease

* (*) mandatory field

Other search option(s)

Suggest an update

(*) Required fields.


Only comments seeking to improve the quality and accuracy of information on the Orphanet website are accepted. For all other comments, please send your remarks via contact us. Only comments written in English can be processed.

Captcha image

Caudal regression sequence

Disease definition

Caudal regression sequence is a rare congenital malformation of the lower spinal segments associated with aplasia or hypoplasia of the sacrum and lumbar spine.


  • Synonym(s):
    • Caudal dysplasia
    • Sacral agenesis syndrome
    • Sacral regression syndrome
  • Prevalence: 1-9 / 100 000
  • Inheritance: Multigenic/multifactorial or Not applicable 
  • Age of onset: Infancy, Neonatal
  • ICD-10: Q76.0
  • OMIM: 600145
  • UMLS: C0300948  C0344490  C1867774  C2609260
  • MeSH: -
  • GARD: 6007
  • MedDRA: 10054842  10059387  10068896
The documents contained in this web site are presented for information purposes only. The material is in no way intended to replace professional medical care by a qualified specialist and should not be used as a basis for diagnosis or treatment.