Orphanet: Parkinsonian pyramidal syndrome

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Parkinsonian-pyramidal syndrome

Disease definition

Parkinsonian-pyramidal syndrome is a rare, genetic, neurological disorder characterized by the association of both parkinsonian (i.e. bradykinesia, rigidity and/or rest tremor) and pyramidal (i.e. increased reflexes, extensor plantar reflexes, pyramidal weakness or spasticity) manifestations, which vary according to the underlying associated disease (e.g. neurodegenerative disease, inborn errors of metabolism).


Classification level: Disorder
  • Synonym(s):
    • Pallidopyramidal syndrome
  • Prevalence: -
  • Inheritance: Autosomal recessive 
  • Age of onset: Adolescent, Adult
  • ICD-10: G20
  • OMIM: 168100  168601  260300
  • UMLS: C1850100
  • MeSH: -
  • GARD: 9175
  • MedDRA: -
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