Orphanet: Combined deficiency of factor V and factor VIII

Search for a rare disease

* (*) mandatory field

Other search option(s)

Suggest an update

(*) Required fields.


Only comments seeking to improve the quality and accuracy of information on the Orphanet website are accepted. For all other comments, please send your remarks via contact us. Only comments written in English can be processed.

Captcha image

Combined deficiency of factor V and factor VIII

Disease definition

Combined deficiency of factor V and factor VIII is an inherited bleeding disorder due to the reduction in activity and antigen levels of both factor V (FV) and factor VIII (FVIII) and characterized by mild-to-moderate bleeding symptoms.


Classification level: Disorder
  • Synonym(s):
    • F5F8D
    • FV and FVIII combined deficiency
    • Familial multiple coagulation factor deficiency
  • Prevalence: 1-9 / 1 000 000
  • Inheritance: Autosomal recessive 
  • Age of onset: All ages
  • ICD-10: D68.8
  • OMIM: 227300  227310  613625
  • UMLS: C1856883
  • MeSH: -
  • GARD: -
  • MedDRA: -

Detailed information

Article for general public

The documents contained in this web site are presented for information purposes only. The material is in no way intended to replace professional medical care by a qualified specialist and should not be used as a basis for diagnosis or treatment.