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Staphylococcal scalded skin syndrome

Disease definition

A rare staphylococcal toxemia caused by epidermolytic toxins of Staphylococcus aureus and characterized by the appearance of widespread erythematous patches, on which large blisters develop. Upon rupture of these blisters, the skin appears reddish and scalded. The lesions typically begin in the face and rapidly expand to other parts of the body. The disease may be complicated by pneumonia and sepsis. It most commonly affects newborns and infants.


Classification level: Disorder
  • Synonym(s):
    • Generalized exfoliative disease
    • SSSS
  • Prevalence: Unknown
  • Inheritance: -
  • Age of onset: All ages
  • ICD-10: L00
  • ICD-11: EA50.2 
  • OMIM: -
  • UMLS: C0038165
  • MeSH: D013206
  • GARD: -
  • MedDRA: 10041929
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