Orphanet: Cushing disease

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Cushing disease

Disease definition

Cushing disease (CD) is the most common cause of endogenous Cushing syndrome (CS; see this term) and is due to pituitary chronic over-secretion of ACTH by a pituitary corticotroph adenoma.


Classification level: Disorder
  • Synonym(s):
    • Corticotroph pituitary adenoma
    • Pituitary corticotroph micro-adenoma
    • Pituitary-dependent Cushing syndrome
  • Prevalence: 1-9 / 100 000
  • Inheritance: Not applicable 
  • Age of onset: Adult
  • ICD-10: D35.2  E24.0
  • OMIM: 219090
  • UMLS: C0010481  C0221406
  • MeSH: D047748
  • GARD: 12867
  • MedDRA: 10035109

Detailed information

Article for general public


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