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Placental site trophoblastic tumor
Placental site trophoblastic tumor is a rare gestational trophoblastic tumor (GTT; see this term) which develops from the placental implantation site and always occurs following pregnancy, voluntary termination of pregnancy (VTP) or miscarriage.
ORPHA:99928Classification level: Disorder
- Prevalence: <1 / 1 000 000
- Inheritance: Not applicable
- Age of onset: Adult
- ICD-10: D39.2
- OMIM: -
- UMLS: C0206666
- MeSH: D018245
- GARD: -
- MedDRA: -
About 200 cases have been described in the literature.
Indicative signs are irregular metrorrhagia some time after spontaneous miscarriage or VTP, presence of metastasis or unexplained metrorrhagia in the weeks and months following normal childbirth or ectopic pregnancy.
Etiology is unknown.
Chorionic gonadotropin (hCG) levels are usually low at about 10 to 100 IU/l (N < 2 to 5 IU/l). Histologically, the myometrium is invaded by intermediate trophoblastic cells without chorionic villi and containing human placental lactogen hormone (hPL). Tissue necrosis is absent and hemorrhage is mild.
Management and treatment
Total hysterectomy is the basic treatment option.