Search for a gene
FUS - FUS RNA binding protein
- Synonym(s) : FUS1, heterogeneous nuclear ribonucleoprotein P2, HNRNPP2, hnRNP-P2, TLS, translocated in liposarcoma
- Previous symbols and names : 'fusion, derived from t(12;16) malignant liposarcoma', ALS6, Fusion, derived from t(12;16) malignant liposarcoma, amyotrophic lateral sclerosis 6, fused in sarcoma, fusion (involved in t(12;16) in malignant liposarcoma)
- Type : gene with protein product
- Chromosomal location : 16p11.2
- OMIM: 137070
- HGNC: 4010
- UniProtKB: P35637
- Genatlas: FUS
- GenCC: FUS
- Ensembl: ENSG00000089280
- IUPHAR-DB: -
- Reactome: P35637
- LOVD: FUS
Diseases list
- Disease-causing germline mutation(s) in Amyotrophic lateral sclerosis
ORPHA:803 
- Disease-causing germline mutation(s) in Juvenile amyotrophic lateral sclerosis
ORPHA:300605 - Part of a fusion gene in Myxofibrosarcoma
ORPHA:79105 - Part of a fusion gene in Myxoid/round cell liposarcoma
ORPHA:99967 - Major susceptibility factor in Frontotemporal dementia with motor neuron disease
ORPHA:275872 - Major susceptibility factor in NON RARE IN EUROPE: Hereditary essential tremor
ORPHA:862
: AssessedAdditional information
Patient-centred resources for this gene
Research activities on this gene
Specialised Social Services
The documents contained in this web site are presented for information purposes only. The material is in no way intended to replace professional medical care by a qualified specialist and should not be used as a basis for diagnosis or treatment.
Orphanet is part of the Gene Curation Coalition, a global effort to harmonise gene-level resources.