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Tumor necrosis factor receptor 1 associated periodic syndrome

Disease definition

Tumor necrosis factor receptor 1 associated periodic syndrome (TRAPS) is a periodic fever syndrome, characterized by recurrent fever, arthralgia, myalgia and tender skin lesions lasting for 1 to 3 weeks, associated with skin, joint, ocular and serosal inflammation and complicated by secondary amyloidosis (see this term).


Classification level: Disorder
  • Synonym(s):
    • Familial Hibernian fever
    • TNF receptor 1-associated periodic syndrome
    • TRAPS syndrome
  • Prevalence: 1-9 / 1 000 000
  • Inheritance: Autosomal dominant 
  • Age of onset: Childhood, Infancy, Adolescent, Adult
  • ICD-10: E85.0
  • ICD-11: 4A60.2
  • OMIM: 142680
  • UMLS: C1275126
  • MeSH: -
  • GARD: 8457
  • MedDRA: -

Detailed information

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ERN : produced/endorsed by ERN(s)
FSMR : produced/endorsed by FSMR(s)
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